Potential utilization Naphthoquinones in a medicine

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F05%3A00086674" target="_blank" >RIV/62156489:43210/05:00086674 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

čeština

Original language name

Potencionální využití naftochinonu v medicíně

Original language description

Naphthoquinones, compounds of natural origin, mostly appeared as chromatic pigments. They are deposited in cells vacuoles, where they are dissolved (in glycoside form). They are synthesised by range of chemical reactions, where shikimate acid, L-alanine,parahydroxybenzoic acid and C10 isoprenoid unit are initial substrates for biosynthesis of juglone, droserone, plumbagin and 7-methyljuglone [1]. In nature they occur in wide range of plants species and also in fungi and microorganisms as group of secondary metabolites. Naphthoquinones are very toxic, their antimicrobial, antifungal, antiviral and antiparasitic effects were observed [2]. An anticancer effect of naphthoquinones awakes an interest in determination and characterization of single derivatesof 1,2 and 1,4 quinone in biological samples. The aim of our work was to optimize the high performance liquid chromatography coupled with diode array detector for the determination of naphtoquinones (1,4-naphtoquinone, lawsone, juglone a

Czech name

Potencionální využití naftochinonu v medicíně

Czech description

Naphthoquinones, compounds of natural origin, mostly appeared as chromatic pigments. They are deposited in cells vacuoles, where they are dissolved (in glycoside form). They are synthesised by range of chemical reactions, where shikimate acid, L-alanine,parahydroxybenzoic acid and C10 isoprenoid unit are initial substrates for biosynthesis of juglone, droserone, plumbagin and 7-methyljuglone [1]. In nature they occur in wide range of plants species and also in fungi and microorganisms as group of secondary metabolites. Naphthoquinones are very toxic, their antimicrobial, antifungal, antiviral and antiparasitic effects were observed [2]. An anticancer effect of naphthoquinones awakes an interest in determination and characterization of single derivatesof 1,2 and 1,4 quinone in biological samples. The aim of our work was to optimize the high performance liquid chromatography coupled with diode array detector for the determination of naphtoquinones (1,4-naphtoquinone, lawsone, juglone a

Type

D - Article in proceedings

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/GP525%2F04%2FP132" target="_blank" >GP525/04/P132: Study of protection mechanisms for stress-induced by heavy metals</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Dny diagnosticke, prediktivni a experimentalni onkologie

ISBN

80-239-6302-3

ISSN

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e-ISSN

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Number of pages

2

Pages from-to

39-40

Publisher name

Solen

Place of publication

Olomouc

Event location

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Event date

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Type of event by nationality

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UT code for WoS article

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