Metallothionein - Zinc- Prostate cancer: Pathogenesis and diagnostic use
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F10%3A00166772" target="_blank" >RIV/62156489:43210/10:00166772 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Metallothionein - Zinc- Prostate cancer: Pathogenesis and diagnostic use
Original language description
Prostate cancer (PCa) is one of the most frequent cancer and one of the most frequent cancerrelated cause of death among men. Therefore, early diagnosis, differentiation between risky and relative benign forms and understanding of pathogenesis of diseasefor further therapeutic approaches is highly desirable. Healthy prostate is unique in zinc accumulation. Zinc is (mostly) buffered by cysteine-rich low molecular protein metallothionein (MT). In contrast, PCa has altered zinc metabolism and elevated MT.In PCa patients, MT is elevated even in serum and can therefore be used as potential tumor marker due to high specifity to PCa. This could be very desirable because of inaccuracies of current prostatic specific antigen (PSA) screening. The aims of thisstudy is (1) to analyze MT-zinc relation on cell lines: to determine zinc and MT levels in cell lines PC-3 (cancer) and PNT1A (control), (2) to find relations between MT and PSA, (3) to describe potential effects of MT and/or zinc on pros
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP301%2F09%2FP436" target="_blank" >GP301/09/P436: Metallothionein analysis in prostate carcinoma at DNA, RNA and protein level.</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
MendelNet 2010 Proceedings of International Ph.D. Students Conference
ISBN
978-80-7375-453-2
ISSN
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e-ISSN
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Number of pages
7
Pages from-to
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Publisher name
Mendelova univerzita v Brně, Agronomická fakulta
Place of publication
Brno
Event location
Brno
Event date
Jan 1, 2000
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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