Alfa-methyl-CoA racemase jako nový marker rakoviny prostaty

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F10%3A00184800" target="_blank" >RIV/62156489:43210/10:00184800 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

čeština

Original language name

Alpha-methylacyl-CoA racemase as a new marker in prostate cancer

Original language description

Prostate cancer is one of the most common forms of cancer among men. Currently, prostate cancer is screened using serum prostatic specific antigen (PSA) value and digital rectal examination. Unfortunately, PSA is not a cancer specific marker and has a low sensitivity and specificity. Gene expression profiling of prostate cancers has lead to the discovery of many novel genes associated with cancers. Alpha-methylacyl-CoA racemase (AMACR) is one such gene which is highly expressed in prostate carcinoma cells compared with normal prostate epithelial cells. AMACR is a peroxisomal and mitochondrial enzyme involved in the b-oxidation of branched fatty acids. It was recently reported that AMACR has very high sensitivity and specificity to prostate adenocarcinoma. Therefore it is very important to find new approaches in AMACR detection.

Czech name

Alpha-methylacyl-CoA racemase as a new marker in prostate cancer

Czech description

Prostate cancer is one of the most common forms of cancer among men. Currently, prostate cancer is screened using serum prostatic specific antigen (PSA) value and digital rectal examination. Unfortunately, PSA is not a cancer specific marker and has a low sensitivity and specificity. Gene expression profiling of prostate cancers has lead to the discovery of many novel genes associated with cancers. Alpha-methylacyl-CoA racemase (AMACR) is one such gene which is highly expressed in prostate carcinoma cells compared with normal prostate epithelial cells. AMACR is a peroxisomal and mitochondrial enzyme involved in the b-oxidation of branched fatty acids. It was recently reported that AMACR has very high sensitivity and specificity to prostate adenocarcinoma. Therefore it is very important to find new approaches in AMACR detection.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/GP301%2F09%2FP436" target="_blank" >GP301/09/P436: Metallothionein analysis in prostate carcinoma at DNA, RNA and protein level.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Chemistry

ISSN

0009-9147

e-ISSN

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Volume of the periodical

56

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

1

Pages from-to

197

UT code for WoS article

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EID of the result in the Scopus database

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