Electrochemical behaviuor of (PRPC) and changed (PRPSC) prion protein
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F11%3A00173966" target="_blank" >RIV/62156489:43210/11:00173966 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Electrochemical behaviuor of (PRPC) and changed (PRPSC) prion protein
Original language description
Prion diseases are fatal neurodegenerative and infectious disorders of humans and animals, characterized by structural transition of the host-encoded cellular prion protein (PrPC) into the aberrantly folded pathologic isoform PrPSc. Prion protein is a biomolecule naturally occurring in the animal cells. This protein is present in all mammal cells and occurs primarily in neural cells and immune system cells. The main aim of this study was to optimize electrochemical methods for the detection of natural (PrPC) and changed (PrPSC) prion protein. To carry out the main objective a complex study of the electrochemical behaviour of both proteins was required. For this purpose fundamental electrochemical techniques were used. Both of the prions were characterized using different techniques, their limits of detection were found at pM levels and possible ability to change the structure of alpha-helix of natural prion (PrPC) to beta-sheet of the infectious prion (PrPSc) were monitored.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CG - Electrochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
XI. pracovní setkání fyzikálních chemiků a elektrochemiků
ISBN
978-80-7375-514-0
ISSN
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e-ISSN
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Number of pages
3
Pages from-to
279-281
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
MENDELU
Event date
Jan 1, 2011
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
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