Electrochemical behaviour of native and denatured b-sheet breaker prion protein

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F12%3A00183681" target="_blank" >RIV/62156489:43210/12:00183681 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/12:PU99117

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Electrochemical behaviour of native and denatured b-sheet breaker prion protein

Original language description

Prion diseases are fatal neurodegenerative and infectious disorders of humans and animals, characterized by structural transition of the host-encoded cellular prion protein (PrPC) into the aberrantly folded pathologic isoform PrPSc. The conformation change, from the a-helix in the natural protein form (PrPc) to the b-sheet of the modified protein form (PrPSc), significantly influence the protein function. The mutated form (PrPSc) is extremely resistant to the cell degradation processes and may bind other PrPc molecules inducing the conformation change to the PrPSc. The insufficiency of the physiological PrPc and toxic incidence of PrPSc participate on the genesis of prion neurodegenerative diseases. The main aim of this study was to suggest electrochemical methods for detection of b-sheet breaker prion protein. For this purpose cyclic voltammetry (CV), differential pulse voltammetry (DPV), differential pulse voltammetry Brdicka reaction and chronopotentiometric stripping analysis (CPSA

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Electrochemical Science

ISSN

1452-3981

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

2

Country of publishing house

RS - THE REPUBLIC OF SERBIA

Number of pages

15

Pages from-to

928-942

UT code for WoS article

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EID of the result in the Scopus database

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