Anthracyclines and ellipticines as DNA-damaging anticancer drugs: Recent advances

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F12%3A00181680" target="_blank" >RIV/62156489:43210/12:00181680 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11320/12:10126251 RIV/00216208:11310/12:10126251 RIV/00216208:11130/12:8059 RIV/00064203:_____/12:8059

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Anthracyclines and ellipticines as DNA-damaging anticancer drugs: Recent advances

Original language description

Over the past forty years, anthracyclines and ellipticines have attracted attention as promising cytostatics. In this review, we focus on their mechanisms of cytoxicity, DNA-damaging effects and adverse side-effects. We also summarize ways to enhance thetherapeutic effects of these drugs together with a decrease in their adverse effects. Current drug design strategies are focused on drug bioavailability and their tissue targeting, whereas drug delivery to specific intracellular compartments is rarely addressed. Therefore, therapies utilizing the antineoplastic activities of anthracyclines and ellipticines combined with novel strategies such as nanotechnologies for safer drug delivery, as well as strategies based on gene therapy, could significantly contribute to medical practice.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmacology and Therapeutics

ISSN

0163-7258

e-ISSN

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Volume of the periodical

133

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

26-39

UT code for WoS article

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EID of the result in the Scopus database

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