Electrochemical study of doxorubicin interaction with different sequences of single stranded oligonucleotides, Part I

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F12%3A00182653" target="_blank" >RIV/62156489:43210/12:00182653 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/12:10123195 RIV/00216305:26620/12:PU95569 RIV/00216224:14310/12:00060306 RIV/00216208:11130/12:8022 RIV/00064203:_____/12:8022

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Electrochemical study of doxorubicin interaction with different sequences of single stranded oligonucleotides, Part I

Original language description

Doxorubicin is a known anticancer drug intercalating into dsDNA. The mechanism of interaction of doxorubicin with ssDNA is not clear. In this study, adsorptive transfer stripping technique coupled with square wave voltammetry was used for studying of interaction of doxorubicin with single stranded oligonucleotides (ssODN) in various ratios (1:1, 1:2 and 1:5) and interaction times (0-300 min.). When comparing the results for three ratios of the mixture between drug and ssODN we found that the interval ofpeak intensities of oligonucleotide reduced with the increasing ratio of oligonucleotide-doxorubicin, i.e. for ratio 1:1 it is 25-85 %, for ratio 1:2 it is 16-60 % and for ratio 1:5 it is 19-51 %. The interval of relative signal intensities of doxorubicin ranges from 8 to 100 % for ratio 1:1, 22-100 % for ratios 1:2 and 1:5. The results showed the assumption that DOXO peak height increased with increasing concentration of the drug intercalated into ssODN, but the signals CA peaks change

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Electrochemical Science

ISSN

1452-3981

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

1

Country of publishing house

RS - THE REPUBLIC OF SERBIA

Number of pages

21

Pages from-to

13-33

UT code for WoS article

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EID of the result in the Scopus database

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