Electrochemical characterization of doxorubicin interaction with DNA

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F12%3A00198451" target="_blank" >RIV/62156489:43210/12:00198451 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Electrochemical characterization of doxorubicin interaction with DNA
Original language description
Doxorubicin as a member of anthracycline antibiotics is one of the most widely used for the treatment of malignant tumours with the ability to interact with DNA. Electrochemistry is considered one of the most sensitive methods for studying DNA [1, 2]. The aim of the study was: i) electrochemical characterization of the interaction of doxorubicin with single and double stranded oligonucleotides, ii) investigation of the influence of different sequence on the interaction, iii) time dependence of the effect of doxorubicin and oligonucleotides. Four different variants of ODN were designed and the influence of sequence on interaction with doxorubicin was investigated. The obtained data were processed showing the correlation dependence of size change of DOXOpeak to peak size change of the peak of each ODN. This dependence was studied also in the time manner (time interaction DOXO with ODN) as 30, 150, 240 and 300 min. The value of [100, 0] represents the initial state of electrochemical ana
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CG - Electrochemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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