Association of PSA level with thiols content in patients with prostate carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F12%3A00198376" target="_blank" >RIV/62156489:43210/12:00198376 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Association of PSA level with thiols content in patients with prostate carcinoma

Original language description

To detect prostate carcinoma, prostatic specific antigen (PSA) is mostly used. However diagnostics of this tumour disease can become more precise using other types of molecules [1]. In this study we aimed at determination of reduced (GSH) and oxidized (GSSG) glutathione and its ratio and level of metallothionein in blood of patients with prostate carcinoma. The obtained results were correlated with PSA levels determined in blood of patients. Analyses were performed in 35 patients with prostate cancer atthe age of 54 to 79 years with an average of 66 years and in 8 healthy subjects who formed the control group. PSA levels in patients ranged from 1.4 to 6.4 ng*ml-1 with an average of 2.4 ng*ml-1, GSH/GSSG from 0.6 to 6.7 with an average of 4.3 and metallothionein content ranged from 0.97 to 2.42 uM with an average of 1.91 uM. In the control group PSA values ranged from 0.06 to 0.14 ng*ml-1 with an average of 0.11 ng*ml-1, GSH/GSSG from 7.8 to 13.8 with an average of 9.4 and metallothion

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GAP301%2F10%2F0356" target="_blank" >GAP301/10/0356: Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Medicine

ISSN

1107-3756

e-ISSN

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Volume of the periodical

30

Issue of the periodical within the volume

1

Country of publishing house

GR - GREECE

Number of pages

1

Pages from-to

47

UT code for WoS article

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EID of the result in the Scopus database

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