Glutathione modified CdTe quantum dots as a label for studying DNA interactions with platinum based cytostatics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F13%3A00199283" target="_blank" >RIV/62156489:43210/13:00199283 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/13:PU104425

Result on the web

<a href="http://dx.doi.org/10.1002/elps.201200664" target="_blank" >http://dx.doi.org/10.1002/elps.201200664</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/elps.201200664" target="_blank" >10.1002/elps.201200664</a>

Result language

angličtina

Original language name

Glutathione modified CdTe quantum dots as a label for studying DNA interactions with platinum based cytostatics

Original language description

Cisplatin, carboplatin, and oxaliplatin represent three generations of platinum based drugs applied successfully for cancer treatment. As a consequence of the employment of platinum based cytostatics in the cancer treatment, it became necessary to studythe mechanism of their action. Current accepted opinion is the formation of Pt-DNA adducts, but the mechanism of their formation is still unclear. Nanomaterials, as a progressively developing branch, can offer a tool for studying the interactions of these drugs with DNA. In this study, fluorescent CdTe quantum dots (QDs, lambda em = 525 nm) were employed to investigate the interactions of platinum cytostatics (cisplatin, carboplatin, and oxaliplatin) with DNA fragment (500 bp, c = 25 microg/mL). Primarily, the fluorescent behavior of QDs in the presence of platinum cytostatics was monitored and major differences in the interaction of QDs with tested drugs were observed. It was found that the presence of carboplatin (c = 0.25 mg/mL) had

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Electrophoresis

ISSN

0173-0835

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

6

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

801-808

UT code for WoS article

316328500001

EID of the result in the Scopus database

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