The influence of polyunsaturated fatty acids on cholesterol homeostasis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F13%3A43908840" target="_blank" >RIV/62156489:43210/13:43908840 - isvavai.cz</a>
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2013/mnet_2013_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2013/mnet_2013_full.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The influence of polyunsaturated fatty acids on cholesterol homeostasis
Original language description
The aim of this work was to validate the hypothesis of a positive influence of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) on the proportion of plasmatic lipids. These polyunsaturated fatty acids can decrease the plasma cholesterol due tothe increase in expression of the gene Insig-1 together with the decrease in expression of the genes coding HMG-CoA-R and LDL-R. Hypothesis had been tested on experimental animals (Rattus norvegicus) that were fed with a standard feeding mixture, with the addition of 3 % fish oil (salmon oil). The expression of the gene Insig-1 in animals livers that had been fed with the feed with the additon of salmon oil was 730 % (P < 0.05) compared to the control. However, on the contrary to the hypothesis, the expression of the gene HMG-CoA-R was 165 % (P > 0.05) and the expression of the gene for LDL-R was 210 % (P > 0.05) compared to the control. Nevertheless, it was proved (P < 0.05) that the fish oil used for the diet of the experimental rats
Czech name
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Czech description
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
MendelNet 2013: Proceedings of International PhD Students Conference
ISBN
978-80-7375-908-7
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
621-625
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 20, 2013
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000366464800107

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