Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F14%3A00225111" target="_blank" >RIV/62156489:43210/14:00225111 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16270/14:43872966 RIV/00216305:26620/14:PU109895
Result on the web
<a href="http://dx.doi.org/10.1002/elps.201300393" target="_blank" >http://dx.doi.org/10.1002/elps.201300393</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/elps.201300393" target="_blank" >10.1002/elps.201300393</a>
Alternative languages
Result language
angličtina
Original language name
Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging
Original language description
Carbon nanomaterials, including fullerenes, exhibit not only unique structure and electronic properties but also a significant potential to serve as radical scavengers and/or anti-oxidants. Their conjugation with anticancer drugs such as doxorubicin (DOX) may help to balance severe negative side effects of these cytostatics and also improve the delivery of the drug taking advantage of the enhanced cellular uptake, selectivity to cancer cells, and pH regulated release. In this study, the fullerene (C60)surface was oxidized by concentrated nitric acid, which enabled simple DOX--fullerene conjugation based on pi-pi stacking and hydrophilic interactions with carboxylic groups. The strength of this noncovalent binding is pH dependent. At a low pH, the amino group of DOX is protonated, however at a higher pH, the amino group is deprotonated, resulting in stronger hydrophobic interactions with the fullerene walls. CE and HPLC were employed for characterization of resulting complexes. The cel
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
O - Projekt operacniho programu
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Electrophoresis
ISSN
0173-0835
e-ISSN
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Volume of the periodical
35
Issue of the periodical within the volume
7
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
1040-1049
UT code for WoS article
333644600016
EID of the result in the Scopus database
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