Experimental and Theoretical Study of Doxorubicin Physicochemical Interaction with BN(O) Drug Delivery Nanocarriers

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F18%3APU130320" target="_blank" >RIV/00216305:26620/18:PU130320 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Experimental and Theoretical Study of Doxorubicin Physicochemical Interaction with BN(O) Drug Delivery Nanocarriers
Original language description
Drug-loaded nanocarriers have a great potential for tumor therapy. Such systems must have high drug-loading efficacy in an alkaline medium and effectively release therapeutic agent in an acidic medium of endosomal/lysosomal compartments of tumor cells. Herein, we experimentally and theoretically (using density functional theory) studied the chemical interaction of doxorubicin (DOX) with different boron nitride (BN) surfaces depending on the degree of their oxidation. Three groups of hexagonal BN nano particles (BNNPs) obtained by boron oxide chemical vapor deposition process, i.e., (i) as-synthesized and those after (ii) repeated washing in water and (iii) high-temperature annealing, and their corresponding DOX-BN conjugates were studied. Oxidation of BNNPs significantly improved their interaction with DOX. As a result, the amount of immobilized DOX on the B2O3 surface was higher in comparison with the BNNPs containing little oxygen. The formation of stable DOX-BN conjugates mainly depended on the attraction of electron density in the area of aromatic rings in the highest occupied molecular orbital of DOX. The presence of a protonated NH2 groups in DOX can facilitate electron density transfer from the DOXH+ to the boron oxide surface.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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