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Ultrafast Electrochemical Trigger Drug Delivery Mechanism for Nanographene Micromachines

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F18%3A43915716" target="_blank" >RIV/60461373:22310/18:43915716 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216305:26620/19:PU131537 RIV/62156489:43210/19:43915012

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/adfm.201806696" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/adfm.201806696</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/adfm.201806696" target="_blank" >10.1002/adfm.201806696</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Ultrafast Electrochemical Trigger Drug Delivery Mechanism for Nanographene Micromachines

  • Original language description

    Nano/micromachines with autonomous motion are the frontier of nanotechnology and nanomaterial research. These self-propelled nano/micromachines convert chemical energy obtained from their surroundings to propulsion. They have shown great potential in diagnostic and therapeutic applications. This work introduces a high-speed tubular electrically conductive micromachine based on reduced nanographene oxide (n-rGO) as a platform for drug delivery and platinum (Pt) as the catalytic inner layer. n-rGO/Pt micromachines are loaded with doxorubicin (DOX) by a simple physical adsorption with a very high loading efficiency, displaying single- or multistrand wrapping of DOX monomers on the micromachine cylinders. More importantly, it is found that electron injection into DOX@n-rGO/Pt micromachines via electrochemistry leads to expulsion of DOX from micromachines in motion within only a few seconds. An in vitro study confirms this efficient release mechanism in the presence of cancerous cells. The unique properties of the n-rGO/Pt micromotor enable the effective management of DOX release at the tumor site and thus enhances the therapeutic efficiency and reduces the side toxicity toward the healthy tissue. These micromachine drug carriers combine the high loading capacity of conventional carbon-based drug carriers with a fast and efficient electrochemical drug-release mechanism

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10402 - Inorganic and nuclear chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Advanced Functional Materials

  • ISSN

    1616-301X

  • e-ISSN

  • Volume of the periodical

    29

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    10

  • Pages from-to

    1806696

  • UT code for WoS article

    000456216900011

  • EID of the result in the Scopus database

    2-s2.0-85057770658