Ultrafast Electrochemical Trigger Drug Delivery Mechanism for Nanographene Micromachines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F19%3A43915012" target="_blank" >RIV/62156489:43210/19:43915012 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/18:43915716 RIV/00216305:26620/19:PU131537
Result on the web
<a href="https://doi.org/10.1002/adfm.201806696" target="_blank" >https://doi.org/10.1002/adfm.201806696</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adfm.201806696" target="_blank" >10.1002/adfm.201806696</a>
Alternative languages
Result language
angličtina
Original language name
Ultrafast Electrochemical Trigger Drug Delivery Mechanism for Nanographene Micromachines
Original language description
Nano/micromachines with autonomous motion are the frontier of nanotechnology and nanomaterial research. These self-propelled nano/micromachines convert chemical energy obtained from their surroundings to propulsion. They have shown great potential in diagnostic and therapeutic applications. This work introduces a high-speed tubular electrically conductive micromachine based on reduced nanographene oxide (n-rGO) as a platform for drug delivery and platinum (Pt) as the catalytic inner layer. n-rGO/Pt micromachines are loaded with doxorubicin (DOX) by a simple physical adsorption with a very high loading efficiency, displaying single- or multistrand wrapping of DOX monomers on the micromachine cylinders. More importantly, it is found that electron injection into DOX@n-rGO/Pt micromachines via electrochemistry leads to expulsion of DOX from micromachines in motion within only a few seconds. An in vitro study confirms this efficient release mechanism in the presence of cancerous cells. The unique properties of the n-rGO/Pt micromotor enable the effective management of DOX release at the tumor site and thus enhances the therapeutic efficiency and reduces the side toxicity toward the healthy tissue. These micromachine drug carriers combine the high loading capacity of conventional carbon-based drug carriers with a fast and efficient electrochemical drug-release mechanism.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
<a href="/en/project/NV15-28334A" target="_blank" >NV15-28334A: Influence of metallothionein on binding of platinum cytostatics to DNA in cancer cells</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Functional Materials
ISSN
1616-301X
e-ISSN
—
Volume of the periodical
29
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
1806696
UT code for WoS article
000456216900011
EID of the result in the Scopus database
2-s2.0-85057770658