Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F14%3A00228468" target="_blank" >RIV/62156489:43210/14:00228468 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/14:PU108617
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods
Original language description
This study points to changes in the properties of liposomes and its functional qualities in task of release of encapsulated drug doxorubicin according to the content of cholesterol in the phospholipid bilayer. The influence of sodium dodecyl sulphate (SDS) addition to liposomal variants was also evaluated too. Three variants of liposomes differing in various concentrations of cholesterol were assessed. Firstly, we focused on the toxicity of all liposomal variants to Staphyloccocus aureus and it was found that the content of cholesterol increases the IC50 values of encapsulated doxorubicin in liposome with higher concentration of cholesterol than in liposome without cholesterol even four times. Further, the new approach to comparing the influence of various liposomes on detection of encapsulated doxorubicin using the electrochemical detection with construction of differential hydrodynamic voltammograms was used. Finally, the fluorescence detection was used to confirm the release of enca
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CG - Electrochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
O - Projekt operacniho programu
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Electrochemical Science
ISSN
1452-3981
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
6
Country of publishing house
RS - THE REPUBLIC OF SERBIA
Number of pages
15
Pages from-to
2993-3007
UT code for WoS article
334493300024
EID of the result in the Scopus database
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