Interaction study of arsenic (III and V) ions with metallothionein gene (MT2A) fragment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43906304" target="_blank" >RIV/62156489:43210/15:43906304 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/15:PU112621
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0141813014005972" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0141813014005972</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijbiomac.2014.09.001" target="_blank" >10.1016/j.ijbiomac.2014.09.001</a>

Result language
angličtina
Original language name
Interaction study of arsenic (III and V) ions with metallothionein gene (MT2A) fragment
Original language description
Arsenic compounds belong to the most controversial agents concerning human health. Arsenic (As) is considered as a top environmental element influencing human health due to its adverse effects including cancer, diabetes, cardiovascular disease, and reproductive or developmental problems. Despite the proven mutagenic, teratogenic and carcinogenic effects, the arsenic compounds are used for centuries to treat infectious diseases. In our work, we focused on studying of interactions of As(III) and/or As(V)with DNA. Interactions between arsenic ions and DNA were monitored by UV/vis spectrophotometry by measuring absorption and fluorescence spectra, atomic absorption spectrometry, electrochemical measurements (square wave voltammetry) and agarose gel electrophoresis. Using these methods, we observed a stable structure of DNA with As(III) within the concentration range 0.4-6.25 mu g mL(-1). Higher As(III) concentration caused degradation of DNA. However, similar effects were not observed for
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
<a href="/en/project/EE2.3.20.0148" target="_blank" >EE2.3.20.0148: International Cooperation in the Field of Nanotechnologies with In Vivo Imaging Techniques</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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