Effect of mercury on porcine ovarian granulosa cells in vitro
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43907987" target="_blank" >RIV/62156489:43210/15:43907987 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41320/15:67386
Result on the web
<a href="http://dx.doi.org/10.1080/10934529.2015.1019805" target="_blank" >http://dx.doi.org/10.1080/10934529.2015.1019805</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/10934529.2015.1019805" target="_blank" >10.1080/10934529.2015.1019805</a>
Alternative languages
Result language
angličtina
Original language name
Effect of mercury on porcine ovarian granulosa cells in vitro
Original language description
The objective of this in vitro study was to examine dose-dependent changes in the secretion activity [progesterone (P-4) and insulin-like growth factor-I (IGF-I)] of porcine ovarian granulosa cells after experimental mercury (Hg) administration, including its apoptotic potential so as to ascertain the possible involvement of Hg in steroidogenesis. Ovarian granulosa cells were incubated with mercuric chloride [mercury (II) chloride or HgCl2] at the doses 50-250 mu g mL(-1) for 18h and compared with control group without Hg addition. Release of P-4 and IGF-I by ovarian granulosa cells was assessed by RIA and apoptosis by TUNEL assay. Observations show that P-4 release by granulosa cells was significantly (P < 0.05) inhibited at all the doses, while IGF-Irelease was not affected at any of the doses used, although a decreasing trend in the release of IGF-I was noted in comparison to control. An increasing trend of apoptosis of granulosa cells was noted, the difference being significant (P
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GG - Zootechnics
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Environmental Science and Health. Part A-Toxic Hazardous Substances & Environmental Engineering
ISSN
1093-4529
e-ISSN
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Volume of the periodical
50
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
839-845
UT code for WoS article
000355407700008
EID of the result in the Scopus database
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