Influence of a storage protocol on sarcosine levels in the human urinary specimens

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43909563" target="_blank" >RIV/62156489:43210/15:43909563 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Influence of a storage protocol on sarcosine levels in the human urinary specimens
Original language description
Urinary metabolomic profiles have recently drawn a lot of attention owing to a debate regarding their possible role as potential clinical markers for prostate cancer. As was shown, amino acid metabolism in cancer patients differs from that in healthy people, and it can be thus utilized in early diagnostics. In this study, we monitored the behavior of potential noninvasive biomarker for prostate carcinoma, sarcosine, involved in the folate metabolism and DNA methylation processes, linked to the progression of prostate carcinoma. To obtain the maximum amount of information, the biochemical parameters (total protein, creatinine, ions, conductivity) were determined using spectrophotometry and electrochemistry. All results were subjected to statistical processing for revealing different correlations between the studied parameters. These metabolites were observed in the urine obtained from healthy subjects and influence of storage conditions (freezing and thawing) on the concentration of addition of sarcosine was monitored.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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