Guidelines for Homology Modeling of Dopamine, Norepinephrine, and Serotonin Transporters
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F16%3A43909787" target="_blank" >RIV/62156489:43210/16:43909787 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/16:PU121945
Result on the web
<a href="http://dx.doi.org/10.1021/acschemneuro.6b00242" target="_blank" >http://dx.doi.org/10.1021/acschemneuro.6b00242</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acschemneuro.6b00242" target="_blank" >10.1021/acschemneuro.6b00242</a>
Alternative languages
Result language
angličtina
Original language name
Guidelines for Homology Modeling of Dopamine, Norepinephrine, and Serotonin Transporters
Original language description
The human dopamine, norepinephrine, and serotonin transporters (hDAT, hNET, and hSERT) are carriers of neurotransmitters and targets for many drugs. Pioneering works in the past three years to elucidate experimental models of the Drosophila dDAT and human hSERT structures will rapidly impact the field of neuroscience. Here, we evaluated automated homology-based human models of these transporters, employing systematic physics-based, knowledge-based, and empirical-based check. Modeling guidelines were conveyed with attention to the central binding site (S1), secondary binding site (S2), and the extracellular loops EL2 and EL4. Application of new experimental models (dDAT and hSERT) will improve the accuracy of homology models, previously utilizing prokaryotic leucine transporter (LeuT) structure, and provide better predictions of ligand interactions, which is required for understanding of cellular mechanisms and for development of novel therapeutics.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Chemical Neuroscience
ISSN
1948-7193
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1607-1613
UT code for WoS article
000388433000016
EID of the result in the Scopus database
2-s2.0-84996503994