Physicochemical Investigation of Stability of Apoferritin with Encapsulated Doxorubicin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F16%3A43910231" target="_blank" >RIV/62156489:43210/16:43910231 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/16:PU122771 RIV/00216208:11310/16:10372820
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2016/mnet_2016_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2016/mnet_2016_full.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Physicochemical Investigation of Stability of Apoferritin with Encapsulated Doxorubicin
Original language description
The many negative side effects of drugs used for treatment of highly diverse diseases, such as cancer, lead in recent years to the development of ways how to target the drug selectively to the diseased tissue while avoiding the healthy cells. Nanocarriers, made from various materials, can serve as a suitable platform for this targeted drug delivery. Herein, we evaluate the long-term stability of nanocarrier based on ubiquitous protein apoferritin with encapsulated doxorubicin. Various properties of the nanocarrier were observed over the course of 12 weeks while stored at various temperatures, such as premature drug release, optical properties of the encapsulated drug, nanocarrier size and surface zeta potential. The nanocarrier showed very good stability for up to 12 weeks with the best results observed with nanocarrier prepared in water and stored at dark at 4 oC.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA14-18344S" target="_blank" >GA14-18344S: Development of nanoparticle-based cytostatics and enzymes for enhanced chemotherapy of human neuroblastomas and study of mechanisms of their action</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
MendelNet 2016: Proceedings of International PhD Students Conference
ISBN
978-80-7509-443-8
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
966-971
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 9, 2016
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
000392968500173