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Using CdTe/ZnSe core/shell quantum dots to detect DNA and damage to DNA

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F17%3A43911543" target="_blank" >RIV/62156489:43210/17:43911543 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216305:26620/17:PU123082

  • Result on the web

    <a href="https://doi.org/10.2147/IJN.S121840" target="_blank" >https://doi.org/10.2147/IJN.S121840</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2147/IJN.S121840" target="_blank" >10.2147/IJN.S121840</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Using CdTe/ZnSe core/shell quantum dots to detect DNA and damage to DNA

  • Original language description

    CdTe/ZnSe core/shell quantum dot (QD), one of the strongest and most highly luminescent nanoparticles, was directly synthesized in an aqueous medium to study its individual interactions with important nucleobases (adenine, guanine, cytosine, and thymine) in detail. The results obtained from the optical analyses indicated that the interactions of the QDs with different nucleobases were different, which reflected in different fluorescent emission maxima and intensities. The difference in the interaction was found due to the different chemical behavior and different sizes of the formed nanoconjugates. An electrochemical study also confirmed that the purines and pyrimidines show different interactions with the core/shell QDs. Based on these phenomena, a novel QD-based method is developed to detect the presence of the DNA, damage to DNA, and mutation. The QDs were successfully applied very easily to detect any change in the sequence (mutation) of DNA. The QDs also showed their ability to detect DNAs directly from the extracts of human cancer (PC3) and normal (PNT1A) cells (detection limit of 500 pM of DNA), which indicates the possibilities to use this easy assay technique to confirm the presence of living organisms in extreme environments.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10406 - Analytical chemistry

Result continuities

  • Project

    <a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Nanomedicine

  • ISSN

    1176-9114

  • e-ISSN

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    14 February

  • Country of publishing house

    NZ - NEW ZEALAND

  • Number of pages

    15

  • Pages from-to

    1277-1291

  • UT code for WoS article

    000394047900003

  • EID of the result in the Scopus database

    2-s2.0-85013187207