The effect of selenium nanoparticles on the antioxidant potential of laboratory rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F17%3A43912538" target="_blank" >RIV/62156489:43210/17:43912538 - isvavai.cz</a>
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2017/mnet_2017_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2017/mnet_2017_full.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The effect of selenium nanoparticles on the antioxidant potential of laboratory rats
Original language description
The aim of the experiment was to determine the influence of different forms of selenium (sodium selenite, selenium nanoparticles) on the antioxidant status of laboratory rats. The male of Wistar albino rats strain were sorted into 4 groups. The first group (n = 5) served as control with no selenium (Se) administration. The second group was fed with mixture containing 1.2 mg/kg/diet of sodium selenite (Na2SeO3). The third (n = 5) and the fourth group (n = 5) were fed with different forms of selenium nanoparticles containing 1.2 mg Se/kg/diet. Selenium nanoparticles were modified by poly(vinylalcohol) (PVA 49 kDa, PVA 100 kDa). After 30 days of experiment, the rats were slaughtered and the total content of selenium in liver and blood tissue and also changes in concentration of reduced (GSH) and oxidized (GSSG) form of glutathione were measured. In liver samples, a statistically significant increase in the amount of selenium was found only in the Na2SeO3 group (by 59%), although the increase occurred in all of the experimental groups. In the blood, the amount of selenium increased for Na2SeO3 and Se-100. These results were statistically significant. GSH and GSSG were statistically significant only in blood samples where GSH was decreased in all the experimental groups (Na2SeO3 by 60%, Se-49 by 56%, Se-100 by 83%) and increased only in the Na2SeO3 group (by 96%).
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
40201 - Animal and dairy science; (Animal biotechnology to be 4.4)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
MendelNet 2017: Proceedings of International PhD Students Conference
ISBN
978-80-7509-529-9
ISSN
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e-ISSN
neuvedeno
Number of pages
5
Pages from-to
285-289
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 8, 2017
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000440194500051