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The effect of selenium nanoparticles on the antioxidant potential of laboratory rats

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F17%3A43912538" target="_blank" >RIV/62156489:43210/17:43912538 - isvavai.cz</a>

  • Result on the web

    <a href="https://mnet.mendelu.cz/mendelnet2017/mnet_2017_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2017/mnet_2017_full.pdf</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The effect of selenium nanoparticles on the antioxidant potential of laboratory rats

  • Original language description

    The aim of the experiment was to determine the influence of different forms of selenium (sodium selenite, selenium nanoparticles) on the antioxidant status of laboratory rats. The male of Wistar albino rats strain were sorted into 4 groups. The first group (n = 5) served as control with no selenium (Se) administration. The second group was fed with mixture containing 1.2 mg/kg/diet of sodium selenite (Na2SeO3). The third (n = 5) and the fourth group (n = 5) were fed with different forms of selenium nanoparticles containing 1.2 mg Se/kg/diet. Selenium nanoparticles were modified by poly(vinylalcohol) (PVA 49 kDa, PVA 100 kDa). After 30 days of experiment, the rats were slaughtered and the total content of selenium in liver and blood tissue and also changes in concentration of reduced (GSH) and oxidized (GSSG) form of glutathione were measured. In liver samples, a statistically significant increase in the amount of selenium was found only in the Na2SeO3 group (by 59%), although the increase occurred in all of the experimental groups. In the blood, the amount of selenium increased for Na2SeO3 and Se-100. These results were statistically significant. GSH and GSSG were statistically significant only in blood samples where GSH was decreased in all the experimental groups (Na2SeO3 by 60%, Se-49 by 56%, Se-100 by 83%) and increased only in the Na2SeO3 group (by 96%).

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    40201 - Animal and dairy science; (Animal biotechnology to be 4.4)

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    MendelNet 2017: Proceedings of International PhD Students Conference

  • ISBN

    978-80-7509-529-9

  • ISSN

  • e-ISSN

    neuvedeno

  • Number of pages

    5

  • Pages from-to

    285-289

  • Publisher name

    Mendelova univerzita v Brně

  • Place of publication

    Brno

  • Event location

    Brno

  • Event date

    Nov 8, 2017

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article

    000440194500051