The influence of different forms of selenium on vitality of laboratory rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F19%3A43917054" target="_blank" >RIV/62156489:43210/19:43917054 - isvavai.cz</a>

Result on the web

<a href="https://mnet.mendelu.cz/mendelnet2019/mnet_2019_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2019/mnet_2019_full.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The influence of different forms of selenium on vitality of laboratory rats

Original language description

The aim of the study was to compare the influence of two forms of selenium (sodium selenite, selenium nanoparticles) on the health status of animal organism. As model animals for this experiment males of the Wistar albino rat were selected and divided into 3 groups of 5 pieces. The first group (n = 5) served as control with no selenium (Se) addition. The second group was fed with mixture containing 1.2 mg/kg of diet of sodium selenite (Na2SeO3). The third group (n = 5) was fed with mixture containing selenium nanoparticles (SeNPs, 1.2 mg Se/kg of diet). The experiment lasted 28 days, during which rats were regularly weighed. At the end of experiment animal were euthanized and samples of liver and small intestine tissue were collected and subjected to histological analysis. Histological analysis showed liver damage in all experimental groups (treated and non-treated) of rats. Another measured parameter was total content of selenium in blood and liver tissue. Analysis showed that the addition of selenium to the feed dose has an effect on increasing amount of selenium in the liver and blood tissues. However, statistically significant difference was observed only in group Na2SeO3 in blood (by 97%). From the results of regular weighing of rats during the experiment, it is apparent that the addition of selenium nanoparticles has no significant effect on weight gain.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

40201 - Animal and dairy science; (Animal biotechnology to be 4.4)

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

MendelNet 2019: Proceedings of International PhD Students Conference

ISBN

978-80-7509-688-3

ISSN

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e-ISSN

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Number of pages

5

Pages from-to

206-210

Publisher name

Mendelova univerzita v Brně

Place of publication

Brno

Event location

Brno

Event date

Nov 6, 2019

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000576735500037