Influence of Antineoplastic Drug Cisplatin and Platinum Nanoparticles on Chicken Embryo Liver and Kidney Amino Acids

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F18%3A43913345" target="_blank" >RIV/62156489:43210/18:43913345 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/18:PU128333

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Influence of Antineoplastic Drug Cisplatin and Platinum Nanoparticles on Chicken Embryo Liver and Kidney Amino Acids

Original language description

Cisplatin (cis-diamminedichloroplatinum II) is cytostatic currently used in the treatment of a various type of solid tumors, including cancers of the ovary, testis, bladder, head and neck, lung, cervix and endometrium. The health effects of platinum are strongly dependent upon the kind of bonds that are shaped and the exposure level and immunity of the person that is exposed. An in vivo interaction study was performed as a comparison of amino acid profiles in chicken embryo tissue before and after application of cisplatin and two platinum nanoparticles covered with polyvinylpyrrolidone. We found that cisplatin directly influences kidney amino acid representation even at low concentrations. In addition, we performed an interaction study that resulted in the determination of breaking points for each of analyzed amino acids. Proline, leucine, valine, serine, glutamine and isoleucine were determined as the most sensitive amino acids. Additionally, we compared amino acid profiles of liver and kidney before and after exposure to cisplatin and platinum nanoparticles. The amount of amino acids after interaction with cisplatin and platinum nanoparticles was significantly reduced (p &lt; 0.05). This fact points at an ability of cisplatin and Pt nanoparticles to induce changes in quantitative composition of amino acids in chicken tissues. Moreover, this confirms that the interactions between cisplatin, platinum nanoparticles and amino acids may act as another factor most likely responsible for adverse effects of cisplatin and platinum nanoparticles on chicken embryo tissues.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

NANOCON 2017: Conference Proceedings

ISBN

978-80-87294-81-9

ISSN

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e-ISSN

neuvedeno

Number of pages

6

Pages from-to

511-516

Publisher name

Tanger Ltd.

Place of publication

Ostrava

Event location

Brno

Event date

Oct 18, 2017

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000452823300084