A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10191551" target="_blank" >RIV/00216208:11310/13:10191551 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/13:10191551 RIV/00216224:14110/13:00070887 RIV/00064203:_____/13:10191551 RIV/00216305:26620/13:PU126704
Result on the web
<a href="http://dx.doi.org/10.3390/ijms141121629" target="_blank" >http://dx.doi.org/10.3390/ijms141121629</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms141121629" target="_blank" >10.3390/ijms141121629</a>
Alternative languages
Result language
angličtina
Original language name
A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin
Original language description
Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a consequence of chemotherapy with doxorubicin. The purpose of this study was to determine the effect of exposure to doxorubicin on the changes in major amino acids in tissue of cardiac muscle (proline, taurine,glutamic acid, arginine, aspartic acid, leucine, glycine, valine, alanine, isoleucine, threonine, lysine and serine). An in vitro interaction study was performed as a comparison of amino acid profiles in heart tissue before and after application of doxorubicin. We found that doxorubicin directly influences myocardial amino acid representation even at low concentrations. In addition, we performed an interaction study that resulted in the determination of breaking points for each of analyz
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
21629-21646
UT code for WoS article
000328624400027
EID of the result in the Scopus database
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