All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10191551" target="_blank" >RIV/00216208:11310/13:10191551 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/13:10191551 RIV/00216224:14110/13:00070887 RIV/00064203:_____/13:10191551 RIV/00216305:26620/13:PU126704

  • Result on the web

    <a href="http://dx.doi.org/10.3390/ijms141121629" target="_blank" >http://dx.doi.org/10.3390/ijms141121629</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/ijms141121629" target="_blank" >10.3390/ijms141121629</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin

  • Original language description

    Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a consequence of chemotherapy with doxorubicin. The purpose of this study was to determine the effect of exposure to doxorubicin on the changes in major amino acids in tissue of cardiac muscle (proline, taurine,glutamic acid, arginine, aspartic acid, leucine, glycine, valine, alanine, isoleucine, threonine, lysine and serine). An in vitro interaction study was performed as a comparison of amino acid profiles in heart tissue before and after application of doxorubicin. We found that doxorubicin directly influences myocardial amino acid representation even at low concentrations. In addition, we performed an interaction study that resulted in the determination of breaking points for each of analyz

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Molecular Sciences

  • ISSN

    1422-0067

  • e-ISSN

  • Volume of the periodical

    14

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    18

  • Pages from-to

    21629-21646

  • UT code for WoS article

    000328624400027

  • EID of the result in the Scopus database