Cooperative Multifunctional Self-Propelled Paramagnetic Microrobots with Chemical Handles for Cell Manipulation and Drug Delivery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F18%3A43914231" target="_blank" >RIV/62156489:43210/18:43914231 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/18:43915743 RIV/00216305:26620/18:PU131599
Result on the web
<a href="https://doi.org/10.1002/adfm.201804343" target="_blank" >https://doi.org/10.1002/adfm.201804343</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adfm.201804343" target="_blank" >10.1002/adfm.201804343</a>
Alternative languages
Result language
angličtina
Original language name
Cooperative Multifunctional Self-Propelled Paramagnetic Microrobots with Chemical Handles for Cell Manipulation and Drug Delivery
Original language description
Autonomous self-propelled micromachines, taking energy from surrounding environment and converting it to their motion, are on the forefront of the research for smart materials in the recent years. Owing to their self-propulsion mechanism, they have demonstrated to be more efficient drug carriers than passive particles. Here, multifunctional superparamagnetic/catalytic microrobots (PM/Pt microrobots) for cell manipulation, anticancer drug loading, and delivery to breast cancer cells are presented. These PM/Pt microrobots are fabricated from superparamagnetic polymer particles with iron oxide in their interior and an external tosylated surface, which is half-covered by a catalytic platinum (Pt) layer. This result in a triple-functionality-tosyl group-rich polymer layer can bind molecules and biological materials, Pt layer can catalyze decomposition of hydrogen peroxide, providing propulsion to the microrobots and magnetic part allows for manipulation by magnetic field. PM/Pt microrobots are able to move as individual robots and to team-up under influence of weak magnetic field by forming chains of the micromachines to perform collective actions, such as capture and transportation of cancer cells. The efficacy of PM/Pt microrobots to perform several tasks without complex surface functionalization steps simplifies the applicability of such multifunctional devices toward diverse biomedical applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
<a href="/en/project/GA16-18917S" target="_blank" >GA16-18917S: The study of sarcosine metabolism and its participation in prostate cancer development</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Functional Materials
ISSN
1616-301X
e-ISSN
—
Volume of the periodical
28
Issue of the periodical within the volume
43
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
"nestrankovano"
UT code for WoS article
000448258800012
EID of the result in the Scopus database
2-s2.0-85052965532