Microrobotic carrier with enzymatically encoded drug release in the presence of pancreatic cancer cells via programmed self-destruction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F22%3A43924095" target="_blank" >RIV/60461373:22310/22:43924095 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/22:43924095 RIV/60461373:22350/22:43924095
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2352940722001299" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2352940722001299</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.apmt.2022.101494" target="_blank" >10.1016/j.apmt.2022.101494</a>
Alternative languages
Result language
angličtina
Original language name
Microrobotic carrier with enzymatically encoded drug release in the presence of pancreatic cancer cells via programmed self-destruction
Original language description
The field of micro/nanorobots is at the forefront of nanotechnology research. Particularly, magnetically propelled micro/nanorobots demonstrate great potential for biomedical applications due to their biocompatibility in biological environments. Herein is a concept of magnetically powered micromachines with a biodegradable polymer and layer containing an incorporated anticancer drug. The microrobot is chemically programmed in such a way that the polymer layer is degraded by the enzymatic activity of lipase, which is overexpressed in pancreatic cancer cells. This causes degradation of the microrobot's polymer layer and, thus, destruction of this robot, releasing the anticancer drug, which in turn kills the pancreatic cancer cell. Magnetic microrobots are based on microspheres made of polycaprolactone (PCL), iron oxide nanoparticles (Fe3O4), and coated polyethyleneimine (PEI) micelles containing the anticancer drug. Lipase, naturally overexpressed specifically in pancreatic cancer cells, triggers the drug release from the micromachines through biodegradation of PCL. The developed PCL-Fe3O4/PEI magnetic microrobots are fully biocompatible and represent a promising tool for programmable drug release that may be useful in many biomedical applications. © 2022
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/NU21-08-00407" target="_blank" >NU21-08-00407: Functional Nanorobots for Navigated Combination Cancer Therapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Applied Materials Today
ISSN
2352-9407
e-ISSN
—
Volume of the periodical
27
Issue of the periodical within the volume
JUN 2022
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
nestrankovano
UT code for WoS article
000804754900001
EID of the result in the Scopus database
2-s2.0-85129966877