Genetic susceptibility to West Nile virus infection in Camargue horses
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F19%3A43915826" target="_blank" >RIV/62156489:43210/19:43915826 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/19:00113017 RIV/62157124:16170/19:43877289 RIV/62157124:16810/19:43877289
Result on the web
<a href="https://doi.org/10.1016/j.rvsc.2019.04.004" target="_blank" >https://doi.org/10.1016/j.rvsc.2019.04.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.rvsc.2019.04.004" target="_blank" >10.1016/j.rvsc.2019.04.004</a>
Alternative languages
Result language
angličtina
Original language name
Genetic susceptibility to West Nile virus infection in Camargue horses
Original language description
West Nile virus (WNV) is a mosquito-borne zoonotic neurotropic virus capable to cause lethal meningoence-phalitis (WNE) in infected hosts such as birds, horses, and humans. Due to their sensitivity, horses serve as sentinel species in areas at risk. We studied a population of Camargue horses living in Southern France in two zones with endemic WNV circulation where WNV outbreaks were recorded in 2000 and 2003-4. Two sets of microsatellite markers located in MHC and Ly49 genomic regions were genotyped as well as multiple SNPs in ten immunity-related candidate gene regions. Associations between genetic polymorphisms and resistance/susceptibility to WNE were tested. While single marker associations were weak, compound two-gene genotypes of SNPs located within the MAVS, NCR2 and IL-10 genes and microsatellites HMS082 and CZMO13 were associated with susceptibility to WNE. Combinations of microsatellite markers CZM009, ABGe17402 and ABGe9019 were associated with simple seroconversion without clinical signs of WNE (resistance). In addition, a distribution of polymorphic markers between WNV-IgG seropositive horses and a control group of WNV-IgG seronegative horses was tested. One SNP in the OAS1 gene (NC_009151.3:g.21961328A > G) was significantly associated with the seropositive phenotype (p(corr) = 0.023; OR = 40.5 CI (4.28; 383.26); RR = 8.18 CI (1.27; 52.89) in the Camargue breed. In compound genotypes, SNP markers for SLC11A1, MAVS, OAS1, TLR4, ADAM17 and NCR2 genes and ten microsatellites showed non-random distribution between seropositive and seronegative groups of horses. Further analysis of associated markers could contribute to our understanding of anti-WNV defense mechanisms in horses.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Research in Veterinary Science
ISSN
0034-5288
e-ISSN
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Volume of the periodical
124
Issue of the periodical within the volume
June
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
284-292
UT code for WoS article
000471085700042
EID of the result in the Scopus database
2-s2.0-85064311594