Biomimetic peptides for active targeting of neuroblastoma cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F19%3A43917163" target="_blank" >RIV/62156489:43210/19:43917163 - isvavai.cz</a>
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2019/mnet_2019_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2019/mnet_2019_full.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Biomimetic peptides for active targeting of neuroblastoma cells
Original language description
This work was focused on anticancer therapy through targeting ligands to raise the treatment efficacy of neuroblastoma, embryonal malignant tumor. Active targeting was attained by surface modifications of apoferritin (EcLHFRT) nanocarriers with encapsulated ellipticine, a potential chemotherapeutic drug. For the purpose of selective delivery of highly potent and highly cytotoxic ellipticine to neuroblastoma cells, surface modification of EcLHFRT nanocarrier was managed by targeting biomimetic peptide ligands, derived from neurotoxin of Conus marmoreus called conotoxin. These peptides exhibit a natural affinity towards human norepinephrine receptor, which is commonly overexpressed on membranes of neuroblastoma cells.
Czech name
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Czech description
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Project
<a href="/en/project/GA17-12816S" target="_blank" >GA17-12816S: Construction of modified apoferritin nanocarriers bearing anticancer drugs and study of mechanisms enhancing their efficiency in anticancer therapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
MendelNet 2019: Proceedings of International PhD Students Conference
ISBN
978-80-7509-688-3
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
695-699
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 6, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000576735500126

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