Optimized assembly of functionalized-neuroblastoma targeting EcLHFRT nanocarriers

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43919628" target="_blank" >RIV/62156489:43210/20:43919628 - isvavai.cz</a>
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Optimized assembly of functionalized-neuroblastoma targeting EcLHFRT nanocarriers
Original language description
Biomimetic peptide ligands designed by using computational biology and in silico chemistry can bring crucial results related to their possible application in targeted anticancer therapy, more specifically in the field of active targeting of malignant neuroblastoma cell lines by modified apoferritin nanocarriers (EcLHFRT) with encapsulated cytotoxic drug. Using the high-performance throughput computing technology, unique peptides (CpTrkA, CpNGF, CpNT4) were designed and synthesized in this work. These peptides showed high affinity in silico to tropomyosin receptor kinases (TrkA, TrkB, TrkC), which are expressed on membranes of neuroblastoma cells. The main aim of this work was detailed characterization of prepared EcLHFRT nanocarriers through which we evaluated the size, stability and hemolytic properties of EcLHFRT with unmodified or modified surface insomuch as mentioned parameters are key for the further research in neuroblastoma nanomedicine. The prepared EcLHFRT nanocarriers possessed optimal size (<50 nm) and stability (ζ~ -20 mV) and in contrast to free cytotoxic drug, they did not cause any hemolysis.
Czech name
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Czech description
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Project
<a href="/en/project/GA17-12816S" target="_blank" >GA17-12816S: Construction of modified apoferritin nanocarriers bearing anticancer drugs and study of mechanisms enhancing their efficiency in anticancer therapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
MendelNet 2020: Proceedings of International PhD Students Conference
ISBN
978-80-7509-765-1
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
603-608
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 11, 2020
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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