Synthesis of poly(lactic-co-glycolic) acid nanoparticles with incorporated fish oil

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43919612" target="_blank" >RIV/62156489:43210/20:43919612 - isvavai.cz</a>
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Synthesis of poly(lactic-co-glycolic) acid nanoparticles with incorporated fish oil
Original language description
Wound healing remains one of the most common and economically demanding health problems in the world. Omega-3 polyunsaturated fatty acids (present in fish oil) are valued for their antiinflammatory property, which is significant in wound healing process. The main aim of this experiment was to develop organic nanoparticles (NPs) made from PLGA poly(lactic-co-glycolic acid) with incorporated fish oil (FO). The PLGA NPs with entrapped fish oil PLGA(FO) NPs synthesized by emulsion evaporation measured 233.3 nm in diameter. Value of PDI was evaluated as 0.351 a.u indicating a polydisperse sample, and the particles were very negatively charged, with a zeta potential of -68.1 mV. Particles were spherical as confirmed by TEM. The initial loading capacity was 22.4 g of FO/mg powder. The entrapment efficiency (EE %) was 22.47 %. The ability of nanodelivered FO on wound healing will be evaluated next.
Czech name
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Czech description
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Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
MendelNet 2020: Proceedings of International PhD Students Conference
ISBN
978-80-7509-765-1
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
557-561
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 11, 2020
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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