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Poly(lactic-co-glycolic) acid nanoparticles as a delivery system for fish oil in wound healing

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F22%3A43921709" target="_blank" >RIV/62156489:43210/22:43921709 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.2754/avb202291030285" target="_blank" >https://doi.org/10.2754/avb202291030285</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2754/avb202291030285" target="_blank" >10.2754/avb202291030285</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Poly(lactic-co-glycolic) acid nanoparticles as a delivery system for fish oil in wound healing

  • Original language description

    The objective of the study was to design, synthetize and characterize poly(lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) with entrapped fish oil (FO) for possible application in a cutaneous wound healing. Morphology of NPs was evaluated by transmission electron microscopy. Antimicrobial characteristics were tested using the disk diffusion method and plate count method, and cytotoxicity was evaluated by the MTT assay. Fish oil (y) was released from PLGA NPs within the time interval (x) of 96 h according to equation y = 6.2 + 0.914x. PLGA-FO NPs did not affect growth of Staphylococcus aureus or methicillin-resistant S. aureus (MRSA) strains. No cytotoxic effect of the tested NPs on the keratinocyte cell line was observed for concentration of 1 µg/ml. PLGA-FO NPs represent an interesting alternative for wound healing due to an excellent biocompatibility and unique release profile of FO, despite their lack of antimicrobial efficiency.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30404 - Biomaterials (as related to medical implants, devices, sensors)

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Acta Veterinaria Brno

  • ISSN

    0001-7213

  • e-ISSN

    1801-7576

  • Volume of the periodical

    91

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    7

  • Pages from-to

    285-291

  • UT code for WoS article

    000834835300009

  • EID of the result in the Scopus database

    2-s2.0-85134492346