Poly(lactic-co-glycolic) acid nanoparticles as a delivery system for fish oil in wound healing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F22%3A43921709" target="_blank" >RIV/62156489:43210/22:43921709 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.2754/avb202291030285" target="_blank" >https://doi.org/10.2754/avb202291030285</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2754/avb202291030285" target="_blank" >10.2754/avb202291030285</a>
Alternative languages
Result language
angličtina
Original language name
Poly(lactic-co-glycolic) acid nanoparticles as a delivery system for fish oil in wound healing
Original language description
The objective of the study was to design, synthetize and characterize poly(lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) with entrapped fish oil (FO) for possible application in a cutaneous wound healing. Morphology of NPs was evaluated by transmission electron microscopy. Antimicrobial characteristics were tested using the disk diffusion method and plate count method, and cytotoxicity was evaluated by the MTT assay. Fish oil (y) was released from PLGA NPs within the time interval (x) of 96 h according to equation y = 6.2 + 0.914x. PLGA-FO NPs did not affect growth of Staphylococcus aureus or methicillin-resistant S. aureus (MRSA) strains. No cytotoxic effect of the tested NPs on the keratinocyte cell line was observed for concentration of 1 µg/ml. PLGA-FO NPs represent an interesting alternative for wound healing due to an excellent biocompatibility and unique release profile of FO, despite their lack of antimicrobial efficiency.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Veterinaria Brno
ISSN
0001-7213
e-ISSN
1801-7576
Volume of the periodical
91
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
7
Pages from-to
285-291
UT code for WoS article
000834835300009
EID of the result in the Scopus database
2-s2.0-85134492346