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Feasible delivery system based on poly(lactictide-co-glycolide) nanoparticles loaded with antimicrobial mupirocin for possible wound healing

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F23%3A43923991" target="_blank" >RIV/62156489:43210/23:43923991 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.2754/avb202392030279" target="_blank" >https://doi.org/10.2754/avb202392030279</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2754/avb202392030279" target="_blank" >10.2754/avb202392030279</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Feasible delivery system based on poly(lactictide-co-glycolide) nanoparticles loaded with antimicrobial mupirocin for possible wound healing

  • Original language description

    The objective of the study was to assess cytotoxicity (based on the dimethylthiazol- diphenyltetrazolium bromide cell viability assay) and antimicrobial effects of poly(lactictide-co-glycolide) nanoparticles with entrapped mupirocin (PLGA/MUP NPs) on Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) strains using a disk-diffusion method, cryo-scanning electron microscopy (cryo-SEM) and fluorescence microscopy. Based on the evaluation of the growth curve, PLGA/MUP NPs inhibited growth of the both tested strains already at a concentration of 0.29 µg/ml, and their inhibitory effect at concentrations from 0.29 to 1.17 µg/ml was comparable with free MUP using the disk-diffusion method. PLGA/MUP NPs also tended to increase the abundance of the dead cells of MRSA, but not of S. aureus, in comparison with free MUP when evaluated by fluorescence microscopy. Further, cryo-SEM evaluation demonstrated an antibacterial-inhibitory effect of PLGA/MUP NPs on S. aureus in a dose-dependent manner. On the other hand, PLGA/MUP NPs cytotoxic activity tended to be substantially lower in comparison with both free MUP and empty PLGA NPs. It can be concluded that the excellent biocompatibility and satisfactory antibacterial effects of PLGA/MUP NPs constitute a suitable alternative as far as cutaneous wound healing is concerned.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/EF16_025%2F0007314" target="_blank" >EF16_025/0007314: Multidisciplinary research to increase application potential of nanomaterials in agricultural practice</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Acta Veterinaria Brno

  • ISSN

    0001-7213

  • e-ISSN

  • Volume of the periodical

    92

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    9

  • Pages from-to

    279-287

  • UT code for WoS article

    001153359000008

  • EID of the result in the Scopus database

    2-s2.0-85168802217