Synthesis and characterization of TiO2 nanoparticles combined with geraniol and their synergistic antibacterial activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F23%3A43923813" target="_blank" >RIV/62156489:43210/23:43923813 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/23:73622204
Result on the web
<a href="https://doi.org/10.1186/s12866-023-02955-1" target="_blank" >https://doi.org/10.1186/s12866-023-02955-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12866-023-02955-1" target="_blank" >10.1186/s12866-023-02955-1</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and characterization of TiO2 nanoparticles combined with geraniol and their synergistic antibacterial activity
Original language description
Background The emergence of antibiotic resistance in pathogenic bacteria has become a global threat, encouraging the adoption of efficient and effective alternatives to conventional antibiotics and promoting their use as replacements. Titanium dioxide nanoparticles (TiO2 NPs) have been reported to exhibit antibacterial properties. In this study, we synthesized and characterized TiO2 NPs in anatase and rutile forms with surface modification by geraniol (GER). Results The crystallinity and morphology of modified TiO2 NPs were analyzed by UV/Vis spectrophotometry, X-ray powder diffraction (XRD), and scanning electron microscopy (SEM) with elemental mapping (EDS). The antimicrobial activity of TiO2 NPs with geraniol was assessed against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), and Escherichia coli. The minimum inhibitory concentration (MIC) values of modified NPs ranged from 0.25 to 1.0 mg/ml against all bacterial strains, and the live dead assay and fractional inhibitory concentration (FIC) supported the antibacterial properties of TiO2 NPs with GER. Moreover, TiO2 NPs with GER also showed a significant decrease in the biofilm thickness of MRSA. Conclusions Our results suggest that TiO2 NPs with GER offer a promising alternative to antibiotics, particularly for controlling antibiotic-resistant strains. The surface modification of TiO2 NPs by geraniol resulted in enhanced antibacterial properties against multiple bacterial strains, including antibiotic-resistant MRSA. The potential applications of modified TiO2 NPs in the biomedical and environmental fields warrant further investigation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/EF16_025%2F0007314" target="_blank" >EF16_025/0007314: Multidisciplinary research to increase application potential of nanomaterials in agricultural practice</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC Microbiology
ISSN
1471-2180
e-ISSN
1471-2180
Volume of the periodical
23
Issue of the periodical within the volume
2 August
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
207
UT code for WoS article
001038909000002
EID of the result in the Scopus database
2-s2.0-85166166413