Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F21%3A43920256" target="_blank" >RIV/62156489:43210/21:43920256 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.3390/ijms221810043" target="_blank" >https://doi.org/10.3390/ijms221810043</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms221810043" target="_blank" >10.3390/ijms221810043</a>
Alternative languages
Result language
angličtina
Original language name
Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction
Original language description
Inflammation is among the core causatives of male infertility. Despite male infertility being a serious global issue, "bits and pieces" of its complex etiopathology stillremain missing. During inflammation, levels of proinflammatory mediators in the male reproductive tract are greater than usual. According to epidemiological research, in numerous cases of male infertility, patients suffer from acute or chronic inflammation of the genitourinary tract which typically occurs without symptoms. Inflammatory responses in the male genital system are inextricably linked to oxidative stress (OS). OS is detrimental to male fertility parameters as it causes oxidative damage to reproductive cells and intracellular components. Multifarious male infertility causative factors pave the way for impairing male reproductive functions via the common mechanisms of OS and inflammation, both of which are interlinked pathophysiological processes, and the occurrence of any one of them induces the other. Both processes may be simultaneously found in the pathogenesis of male infertility. Thus, the present article aims to explain the role of inflammation and OS in male infertility in detail, as well as to show the mechanistic pathways that link causative factors of male reproductive tract inflammation, OS induction, and oxidant-sensitive cellular cascades leading to male infertility.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1661-6596
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
18
Country of publishing house
CH - SWITZERLAND
Number of pages
20
Pages from-to
10043
UT code for WoS article
000699720700001
EID of the result in the Scopus database
2-s2.0-85115105953