Cytokinin modulates the metabolic network of sulfur and glutathione
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F22%3A43922555" target="_blank" >RIV/62156489:43210/22:43922555 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/22:00128153
Result on the web
<a href="https://doi.org/10.1093/jxb/erac391" target="_blank" >https://doi.org/10.1093/jxb/erac391</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/jxb/erac391" target="_blank" >10.1093/jxb/erac391</a>
Alternative languages
Result language
angličtina
Original language name
Cytokinin modulates the metabolic network of sulfur and glutathione
Original language description
The phytohormone cytokinin is implicated in a range of growth, developmental, and defense processes. A growing body of evidence supports a crosstalk between cytokinin and nutrient signaling pathways, such as nitrate availability. Cytokinin signaling regulates sulfur-responsive gene expression, but the underlying molecular mechanisms and their impact on sulfur-containing metabolites have not been systematically explored. Using a combination of genetic and pharmacological tools, we investigated the interplay between cytokinin signaling and sulfur homeostasis. Exogenous cytokinin triggered sulfur starvation-like gene expression accompanied by a decrease in sulfate and glutathione content. This process was uncoupled from the activity of the major transcriptional regulator of sulfate starvation signaling SULFUR LIMITATION 1 and an important glutathione-degrading enzyme, gamma-glutamyl cyclotransferase 2;1, expression of which was robustly up-regulated by cytokinin. Conversely, glutathione accumulation was observed in mutants lacking the cytokinin receptor ARABIDOPSIS HISTIDINE KINASE 3 and in cytokinin-deficient plants. Cytokinin-deficient plants displayed improved root growth upon exposure to glutathione-depleting chemicals which was attributed to a higher capacity to maintain glutathione levels. These results shed new light on the interplay between cytokinin signaling and sulfur homeostasis. They position cytokinin as an important modulator of sulfur uptake, assimilation, and remobilization in plant defense against xenobiotics and root growth. Cytokinins induce transcriptional changes similar to sulfate starvation response and modulate the contents of sulfur-containing metabolites.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Experimental Botany
ISSN
0022-0957
e-ISSN
1460-2431
Volume of the periodical
73
Issue of the periodical within the volume
22
Country of publishing house
GB - UNITED KINGDOM
Number of pages
17
Pages from-to
7417-7433
UT code for WoS article
000881979400001
EID of the result in the Scopus database
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