Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F23%3A43923738" target="_blank" >RIV/62156489:43210/23:43923738 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.3389/fnut.2023.1126579" target="_blank" >https://doi.org/10.3389/fnut.2023.1126579</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnut.2023.1126579" target="_blank" >10.3389/fnut.2023.1126579</a>

Result language

angličtina

Original language name

Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis

Original language description

Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to persistent inflammatory action of the gastrointestinal tract (GIT) because of an improperly managed immunological reactivity to the intestinal microbiota found in the GIT. The immune response to common commensal microbes plays an essential role in intestinal inflammation related to UC synbiotics, and it is an important element in the optimal therapy of UC. Therefore, synbiotics, i.e., a mixture of prebiotics and probiotics, may help control the diseased state. Synbiotics alleviate the inflammation of the colon by lowering the reactive oxygen species (ROS) and improving the level of antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD). Prebiotic supplementation is not a common practice at the moment, despite numerous research findings proving that the benefits of both probiotics and prebiotics encourage their continued existence and positioning in the GIT, with positive effects on human health by managing the inflammatory response. However, the fact that there have been fewer studies on the treatment of UC with different probiotics coupled with selected prebiotics, i.e., synbiotics, and the outcomes of these studies have been very favorable. This evidence-based study explores the possible role of ROS, SOD, and synbiotics in managing the UC. The proposed review also focuses on the role of alteration of gut microbiota, antioxidant defense in the gastrointestinal tract, and the management of UC. Thus, the current article emphasizes oxidative stress signaling in the GI tract, oxidative stress-based pathomechanisms in UC patients, and UC therapies inhibiting oxidative stress&apos; effects.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30304 - Public and environmental health

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Nutrition

ISSN

2296-861X

e-ISSN

2296-861X

Volume of the periodical

10

Issue of the periodical within the volume

20 July

Country of publishing house

CH - SWITZERLAND

Number of pages

12

Pages from-to

1126579

UT code for WoS article

001041782800001

EID of the result in the Scopus database

2-s2.0-85166747218