Synergistic anti-bacterial effects of green synthesized Zinc oxide nanoparticles with levofloxacin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F23%3A43924002" target="_blank" >RIV/62156489:43210/23:43924002 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.jksus.2023.102905" target="_blank" >https://doi.org/10.1016/j.jksus.2023.102905</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jksus.2023.102905" target="_blank" >10.1016/j.jksus.2023.102905</a>

Result language

angličtina

Original language name

Synergistic anti-bacterial effects of green synthesized Zinc oxide nanoparticles with levofloxacin

Original language description

Nowadays, the emergence of drug resistance was a major problem due to the limited bioavailability and unintended toxicity of antibiotics because of non-specific targeting leading to difficulty to eradicate pathogenic infections. Zinc oxide nanoparticles gain much attention as nanocarriers, due to their non-toxic, eco-friendly, and economical cost, to treat severe pathogenic infections. The purpose of this research was to produce and analyze zinc oxide nanoparticles (ZnONPs) functions using a green synthesis process to evaluate its anti-bacterial and biofilm inhibitory activities against gram-positive and -negative microorganisms. ZnONPs were formed via a green synthetic approach using a seed extract of soybean (Glycine max) and nanoparticles characterization was done using FESEM, X-ray diffraction, UV-VIS spectroscopy, and EDAX. The anti-bacterial and biofilm inhibitory activities of ZnONPs, levofloxacin, and levofloxacin-loaded ZnONPs were determined using agar disc diffusion assay and microtiter plate assay, respectively. Levofloaxcin-loaded ZnONPs showed more potent and statistically significant antibacterial activity than ZnONPs alone against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis. The bacterial inhibition zone of levofloxacin-loaded ZnONPs at 80 µg/ml concentrations was higher in comparison to the standard levofloxacin and ZnONPs alone which showed levofloxacin-loaded ZnONPs possess effective antibacterial activity that prevent the growth of diverse microorganisms. Our findings revealed that levofloxacin-loaded ZnONPs have an effective wide range of antimicrobial effects and could be used for the eradication of pathogenic infections.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

21001 - Nano-materials (production and properties)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of King Saud University - Science

ISSN

1018-3647

e-ISSN

2213-686X

Volume of the periodical

35

Issue of the periodical within the volume

8

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

102905

UT code for WoS article

001085376500001

EID of the result in the Scopus database

2-s2.0-85172011998