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Zinc effects on bacteria: insights from Escherichia coli by multi-omics approach

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F23%3A43924434" target="_blank" >RIV/62156489:43210/23:43924434 - isvavai.cz</a>

  • Alternative codes found

    RIV/62156489:43510/23:43924434

  • Result on the web

    <a href="https://doi.org/10.1128/msystems.00733-23" target="_blank" >https://doi.org/10.1128/msystems.00733-23</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1128/msystems.00733-23" target="_blank" >10.1128/msystems.00733-23</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Zinc effects on bacteria: insights from Escherichia coli by multi-omics approach

  • Original language description

    In this study, we investigated the impact of zinc oxide (ZnO) and zinc oxide nanoparticles (ZnONPs) on Escherichia coli. These compounds are commonly used as fertilizers and feed additives and may have unintended consequences on bacteria. We conducted phenotypic and multi-omics analyses of E. coli exposed to sub-lethal concentrations of ZnO and ZnONPs for 40 sub-culturings and 20 sub-culturings with zinc followed by 20 sub-culturings without zinc in an attempt to reverse zinc effects. An extended treatment with ZnO for 40 sub-culturings had the greatest impact leading to bacterial resistance to aminoglycosides, cephalosporins, and sulfonamides while the treatment with ZnONPs for 40 sub-culturings led to the elevated MIC to chloramphenicol only. Cells exposed to these treatments were thicker and had retarded growth in elevated temperatures. Importantly, zinc withdrawal reversed most phenotypic changes. Zinc exposure caused dramatic changes in cell transcripts and proteins with a role in antibiotic response, heat stress, growth regulation, cell shape, and biofilm formation. An extended zinc exposure led to overall major alterations in E. coli biology and resulted in multi-drug resistance.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

    <a href="/en/project/EF19_073%2F0016670" target="_blank" >EF19_073/0016670: Internal grants of Mendel University in Brno</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    mSystems

  • ISSN

    0021-9193

  • e-ISSN

    2379-5077

  • Volume of the periodical

    8

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    24

  • Pages from-to

    "e00733"-23

  • UT code for WoS article

    001099052000001

  • EID of the result in the Scopus database

    2-s2.0-85180332640