Nanoparticles combined with cefixime as an effective synergistic strategy against Salmonella enterica typhi

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43410%2F21%3A43919884" target="_blank" >RIV/62156489:43410/21:43919884 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.sjbs.2021.05.032" target="_blank" >https://doi.org/10.1016/j.sjbs.2021.05.032</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sjbs.2021.05.032" target="_blank" >10.1016/j.sjbs.2021.05.032</a>

Result language

angličtina

Original language name

Nanoparticles combined with cefixime as an effective synergistic strategy against Salmonella enterica typhi

Original language description

Enteric fever caused by Salmonella typhi has been the most crucial health issue in rural people, especially in Southeast Asia and Africa. Another disease, Salmonellosis, caused by a large group of bacteria of the genus Salmonella, cause substantial economic loss resulting from mortality and morbidity. Higher concentration and repeated use of antibiotics to treat these diseases will likely develop antibiotic resistance among the microbes. The nanoparticle has good penetration power and can kill microbes. Combining two strategies by using nanoparticles with antibiotics kills microbes and reduces the chances of the development of antibiotics resistance. Silver, Nickel, Copper, and Zinc oxide Nanoparticles were chemically synthesized and characterized in this study. Silver nanoparticles at a concentration of 10 µg/ml inhibit all the strains under study. In comparison, silver nanoparticles (16.90 µg/ml), Nickel nanoparticles (83 µg mlMINUS SIGN 1), Copper nanoparticles (249 µg mlMINUS SIGN 1), and Zinc oxide (1614 µg mlMINUS SIGN 1) along with 50 µg/ml cefixime gave maximum zone of inhibition of 35 mm, 19 mm, 31 mm and 23 mm respectively. The antimicrobial assay showed that silver nanoparticles presented good antibacterial performance against all multi-drug-resistant pathogenic Salmonella sp alone as well as in combinations. The present study proved that silver nanoparticles at the lowest concentration along with cefixime could be a possible alternative to control the multi-drug-resistant pathogens.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30107 - Medicinal chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Saudi Journal of Biological Sciences

ISSN

1319-562X

e-ISSN

—

Volume of the periodical

28

Issue of the periodical within the volume

8

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

4164-4172

UT code for WoS article

000682931000009

EID of the result in the Scopus database

2-s2.0-85106971467