Covalent Antithrombin-heparin complex (ATH): an alternative to heparin for arterial thrombosis prevention

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F01%3A00000732" target="_blank" >RIV/62157124:16170/01:00000732 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Covalent Antithrombin-heparin complex (ATH): an alternative to heparin for arterial thrombosis prevention
Original language description
The anticoagulant effect of heparin is expressed through activation of antithrombin (AT). We have developed a novel covalent AT-heparin complex (ATH) that has higher specific activity than unfractionated heparin (UFH) (750 and 180 U/mg, respectively) andinhibits thrombin more rapidly than equimolar concentrations of AT plus UFH (second order rate constants of 3.1 x 109M-1s-1 and 1.0 x 108M-1s-1, respectively). Because of its superior anticoagulant properties, ATH may be better than UFH for prevention ofarterial thrombosis. To explore this possibility, we compared the efficacy and safety of ATH with UFH in rabbit arterial thrombosis prevention and bleeding ear models. Thrombosis in the distal aorta was triggered by a combination of a balloon injury andstenosis produced by application of an external constrictor. Blood flow of the damaged was continuously monitored using an ultrasonic flow probe placed distally to the constrictorAfter 90 min, the extent of thrombosis also was assessed b
Czech name
—
Czech description
—

Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
43th Annual Meeting of the American Society of Hematology
ISBN
—
ISSN
—
e-ISSN
—
Number of pages
1
Pages from-to
—
Publisher name
nezjištěn
Place of publication
nezjištěno
Event location
Orlando, Florida
Event date
Dec 7, 2001
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
—

Similar results(10)