Covalent Antithrombin-heparin complex coated catheter prevents thrombosis in a rabbit central venous catheter model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F01%3A00000733" target="_blank" >RIV/62157124:16170/01:00000733 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Covalent Antithrombin-heparin complex coated catheter prevents thrombosis in a rabbit central venous catheter model
Original language description
Central venous cathetrization is an essential part of modern medicine and plays a life-saving role in different groups of patients. However, obstruction due to clotting is a common problem with central venous catheters (CVCs). Surface modification of biomaterials used for manufacturing CVCs has been attempted to prevent thrombus formation. Although heparin coating is widely used for this purpose, it is far from ideal because of problems with leaching of surface-bound anticoagulant, non-uniform coating and variation in anticoagulant activities of the product. We have developed an antithrombin-heparin covalent complex (ATH) using unfractionated heparin (UFH) and antithrombin (AT). ATH has unique anticoagulant and antithrombotic properties. It has much higher anti-thrombin and anti-factor Xa activities compared to non-covalent mixtures of UFH and AT. Based on these characteristics we compared the thromboresistance of ATH-coated polyurethane (PU) catheters with uncoated or heparin-coated c
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
18th Congress of the International Society on Thrombosis and Haemostasis
ISBN
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ISSN
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e-ISSN
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Number of pages
1
Pages from-to
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Publisher name
nezjištěn
Place of publication
nezjištěno
Event location
Paris
Event date
Jun 6, 2001
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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