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Covalent Antithrombin-heparin complex coated catheter prevents thrombosis in a rabbit central venous catheter model

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F01%3A00000733" target="_blank" >RIV/62157124:16170/01:00000733 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Covalent Antithrombin-heparin complex coated catheter prevents thrombosis in a rabbit central venous catheter model

  • Original language description

    Central venous cathetrization is an essential part of modern medicine and plays a life-saving role in different groups of patients. However, obstruction due to clotting is a common problem with central venous catheters (CVCs). Surface modification of biomaterials used for manufacturing CVCs has been attempted to prevent thrombus formation. Although heparin coating is widely used for this purpose, it is far from ideal because of problems with leaching of surface-bound anticoagulant, non-uniform coating and variation in anticoagulant activities of the product. We have developed an antithrombin-heparin covalent complex (ATH) using unfractionated heparin (UFH) and antithrombin (AT). ATH has unique anticoagulant and antithrombotic properties. It has much higher anti-thrombin and anti-factor Xa activities compared to non-covalent mixtures of UFH and AT. Based on these characteristics we compared the thromboresistance of ATH-coated polyurethane (PU) catheters with uncoated or heparin-coated c

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    GJ - Diseases and animal vermin, veterinary medicine

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2001

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    18th Congress of the International Society on Thrombosis and Haemostasis

  • ISBN

  • ISSN

  • e-ISSN

  • Number of pages

    1

  • Pages from-to

  • Publisher name

    nezjištěn

  • Place of publication

    nezjištěno

  • Event location

    Paris

  • Event date

    Jun 6, 2001

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article