Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F01%3A00000745" target="_blank" >RIV/62157124:16170/01:00000745 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio

Original language description

: The aim of this work was to evaluate the response of dogs with pituitary-dependent hyperadrenocorticism to treatment with mitotane. The relationship between duration of initial phase of therapy and the initial value of urine cortisol/creatinine ratio(UCCR) was studied. All 14 dogs with pituitary-dependent hyperadrenocorticism were treated. Therapeutic protocol of selective adrenocorticolysis was used. The induction dose of mitotane was 25 mg/kg daily. The length of initial phase of therapy was dete rmined individually on the basis of cortisol production changes, which were monitored by immunoreactive cortisol in urine (UCCR) every 2 - 5 days during the initial phase of treatment. High-dose dexamethasone suppression test was used to differentiate between the pituitary-dependent and adrenal-dependent form of the disease, and the UCCR was measured after dexamethasone suppression. The value of the initial UCCR fluctuated between 58-586 x 10-6 , the median of UCCR was 138 x 10-6 . Initial

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta veterinaria

ISSN

0001-7213

e-ISSN

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Volume of the periodical

70

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

313-320

UT code for WoS article

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EID of the result in the Scopus database

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