Diagnostic urography of renal disorders in rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F04%3A00000111" target="_blank" >RIV/62157124:16170/04:00000111 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Diagnostic urography of renal disorders in rats
Original language description
Simple intravenous administration of a contrast medium for excretion urography was tested in 12 clinically healthy female rats (Rattus norvegicus, Wistar), aged from 3 to 8 months, whose weight ranged from 270 to 320 g. Excretion urography was performedin 6 rats. The rats were sedated with a combination of ketamine (40 mg(.)kg(-1) i.m.) and diazepam (5 mg(.)kg(-1), i.m.). Intravenous administration to vena cephalica antebrachii was used in three rats, and intravenous administration to vena saphena lateralis in nine rats. Meglumine (800 mg I(2)(.)kg(-1)) was used as the contrast medium in two rats while iopamidol (800 mg I(2)(.)kg(-1)) was used in the remaining animals. Administration of iopamidol to v. saphena lateralis proved to be the best choice. Excretion urography was performed at the intervals of 15 sec, 1 min, 5, 10, and 20 min. The rats were also sampled for blood, their urine was subjected to basic tests, and a renal biopsy was taken and histological examination of the kidney
Czech name
Diagnostická urografie poruch ledvin u potkanů
Czech description
Diagnostická urografie poruch ledvin u potkanů

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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