Serial translocation by means of circular intermediates underlies colour sidedness in cattle

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F12%3A43872305" target="_blank" >RIV/62157124:16170/12:43872305 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1038/nature10757" target="_blank" >http://dx.doi.org/10.1038/nature10757</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/nature10757" target="_blank" >10.1038/nature10757</a>

Result language

angličtina

Original language name

Serial translocation by means of circular intermediates underlies colour sidedness in cattle

Original language description

Colour sidedness is a dominantly inherited phenotype of cattle characterized by the polarization of pigmented sectors on the flanks, snout and ear tips. It is also referred to as 'lineback' or 'witrik' (which means white back), as colour-sided animals typically display a white band along their spine. Colour sidedness is documented at least since the Middle Ages and is presently segregating in several cattle breeds around the globe, including in Belgian blue and brown Swiss. Here we report that colour sidedness is determined by a first allele on chromosome 29 (Cs(29)), which results from the translocation of a 492-kilobase chromosome 6 segment encompassing KIT to chromosome 29, and a second allele on chromosome 6 (Cs(6)), derived from the first by repatriation of fused 575-kilobase chromosome 6 and 29 sequences to the KIT locus. We provide evidence that both translocation events involved circular intermediates. This is the first example, to our knowledge, of a phenotype determined by ho

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature

ISSN

0028-0836

e-ISSN

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Volume of the periodical

482

Issue of the periodical within the volume

7383

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

81-"U103"

UT code for WoS article

000299726000039

EID of the result in the Scopus database

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