Induction of matrix metalloproteinase-2 and IL-1 in bovine keratinocytes by histamine.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F13%3A43872472" target="_blank" >RIV/62157124:16170/13:43872472 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Induction of matrix metalloproteinase-2 and IL-1 in bovine keratinocytes by histamine.
Original language description
Hoof diseases in dairy cows are an important research topic, where the most common problem is laminitis. Complete causes of this disease are still not fully understood. The critical period for the formation of laminitis is after the parturition when is increased demands for milk production and the food composition changes. This can cause a rumen acidosis where the rumen microflora also produces histamine, acting mainly on local microcirculation in hoofs. Many studies in vivo and in vitro have shown thatkeratinocytes are capable to produce matrix metalloproteinase -2 (MMP -2), which expression during laminitis is increased, and the cytokine IL- 1, which triggers a cascade of inflammation retroactively. Purpose of the project was induction cultures of bovine keratinocytes by various concentrations of histamine. Histamine was applied to the medium at a range of concentrations from the physiological to allergic reactions in plasma (0.15 to 1.0 mg / ml). At 24, 48 and 72 hours the concentr
Czech name
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Czech description
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Project
<a href="/en/project/QI91A238" target="_blank" >QI91A238: Efficient approaches in dairy herd management</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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