Caspase-7 in development of ectodermal organs: Apoptosis or differentiation?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F14%3A43873328" target="_blank" >RIV/62157124:16170/14:43873328 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Caspase-7 in development of ectodermal organs: Apoptosis or differentiation?
Original language description
Several organs are derived from the ectoderm. Development of these structures is controlled by interplay of proliferation, differentiation and cell death mainly mediated by caspase activation. Caspase-7 together with caspases-3 and -6 belongs to the trioof executive caspases. Despite the primary pro-apoptotic character of these caspases, they have been supposed to play roles in non-apoptotic events. Such non-apoptotic function for caspase-7 was revealed in our laboratory when cleaved caspase-7 was found during differentiation of odontoblasts, ameloblasts, osteoblasts and in other non-apoptotic cells. To find out if such non-apoptotic role of caspase-7 might be linked also to development of other ectoderm-derived organs, mouse hair follicles were investigated. Immunohistochemistry was used to detect cleaved (activated) caspase-7 and correlate its presence with occurrence of apoptosis. To reveal the specific influence of caspase-7 on apoptotic signalling networks, changes of expression
Czech name
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Czech description
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Project
<a href="/en/project/GAP502%2F12%2F1285" target="_blank" >GAP502/12/1285: Apoptotic and non-apoptotic functions of caspases in hard tissue formation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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