Atypical myopathy - metabolite profiling of equine serum and urine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F15%3A43874004" target="_blank" >RIV/62157124:16170/15:43874004 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Atypical myopathy - metabolite profiling of equine serum and urine
Original language description
Acquired equine multiple acyl-CoA dehydrogenase deficiency also known as atypical myopathy (AM), is a highly fatal muscle disease of grazing horses which in at least 75 % of cases leads to death. It is probably caused by ingestion of Acer pseudoplatanusseeds containing hypoglycin A, whose active metabolite is responsible for an inhibition of some dehydrogenases (short and medium chain acyl-CoA dehydrogenases, isovaleryl-CoA dehydrogenase etc.). The aim of this work was to perform whole metabolomic analysis in order to find other metabolic pathways which may be affected. Nine serum and six urine samples from horses with AM and twelve control samples were collected and then analyzed using high performance liquid chromatography (Ultimate 3000, Dionex) with aminopropyl column (Luna 3 ?m NH2, 2 x 100 mm, Phenomenex) coupled to tandem mass spectrometry (QTRAP 5500, AB Sciex). The results of equine serum and urine analyses show obvious separation of group with AM and control group. The diffe
Czech name
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Czech description
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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