Hyaluronic acid and TGF-?1 in dogs with hepatobiliary diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F18%3A43876372" target="_blank" >RIV/62157124:16170/18:43876372 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/18:43876372
Result on the web
<a href="http://dx.doi.org/10.2754/avb201887030231" target="_blank" >http://dx.doi.org/10.2754/avb201887030231</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2754/avb201887030231" target="_blank" >10.2754/avb201887030231</a>
Alternative languages
Result language
angličtina
Original language name
Hyaluronic acid and TGF-?1 in dogs with hepatobiliary diseases
Original language description
The aim of the study was to assess serum hyaluronic acid (HA) and transforming growth factor beta 1 (TGF-?1) concentrations: 1) to differentiate hepatic fibrosis from other forms of liver disease, and 2) for the non-invasive staging of canine liver fibrosis. We also evaluated the association between serum HA concentration and the size of the shunt vessel as an indirect marker of decreased liver clearance in patients with single congenital vascular anomaly. Forty-one healthy client-owned dogs and forty dogs diagnosed with hepatobiliary disease were enrolled in the prospective study. Patients were divided into 4 subgroups: 1) congenital portosystemic shunts (CPSS); 2) parenchymal diseases (a. mild and moderate fibrosis, b. advanced fibrosis and cirrhosis); 3) hepatic neoplasia; 4) biliary tract disorders based on thorough clinical, ultrasound and histopathological examination. Serum HA and TGF-?1 concentrations were measured using ELISA. The HA concentration was significantly increased in patients with advanced liver fibrosis/cirrhosis (P < 0.001) and CPSS (P < 0.001) compared to healthy dogs. Using a cut-off HA concentration of 135.94 ng/ml, the sensitivity and specificity for diagnosis for advanced liver fibrosis/cirrhosis was 100% (95% CI, 50.6?100) and 90.8% (95% CI, 81.6?95.7), respectively. The TGF-?1 levels did not significantly differ among groups (P = 0.180). Negligible correlation was found between serum HA concentration and the size of portosystemic shunt vessel (rs = 0.07; P = 0.831). These findings suggest that serum HA concentration is a potential non-invasive biomarker for advanced liver fibrosis and/or cirrhosis in dogs. The utility of measuring serum concentration of TGF-?1 for diagnosing canine liver fibrosis was not supported.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30502 - Other medical science
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta veterinaria Brno
ISSN
0001-7213
e-ISSN
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Volume of the periodical
87
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
10
Pages from-to
231-240
UT code for WoS article
000456052200006
EID of the result in the Scopus database
2-s2.0-85055247519